GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2243480 | 1 | rs6964245 | chr7:65718717 | CCT6P1 | chr7:65216092-65228661:+ | -0.33 | -4.52 | 8.25E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs6964530 | chr7:65718851 | CCT6P1 | chr7:65216092-65228661:+ | -0.29 | -3.93 | 0.000101 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs6966322 | chr7:65646754 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.71 | 3.52E-6 | Diabetic kidney disease |
| BLCA | cis | rs6967385 | 1 | rs6967385 | chr7:12391319 | VWDE | chr7:12370509-12443852:- | -0.31 | -5.17 | 3.79E-7 | Response to taxane treatment (placlitaxel) |
| BLCA | cis | rs2243480 | 1 | rs6970243 | chr7:65388490 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.47 | 1.02E-5 | Diabetic kidney disease |
| BLCA | cis | rs2285947 | 1 | rs6970597 | chr7:21583519 | DNAH11 | chr7:21582833-21941455:+ | -0.3 | -4.99 | 9.08E-7 | Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) |
| BLCA | cis | rs2285947 | 1 | rs6970985 | chr7:21583597 | DNAH11 | chr7:21582833-21941455:+ | -0.3 | -4.98 | 9.83E-7 | Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) |
| BLCA | cis | rs4727443 | 1 | rs6974373 | chr7:99590893 | TRIM4 | chr7:99488037-99517154:- | -0.22 | -4.08 | 5.56E-5 | Interstitial lung disease |
| BLCA | cis | rs2243480 | 1 | rs6974723 | chr7:65637939 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.71 | 3.52E-6 | Diabetic kidney disease |
| BLCA | cis | rs6976053 | 1 | rs6976053 | chr7:100512119 | UFSP1 | chr7:100486346-100487339:- | -0.24 | -4 | 7.64E-5 | Plasminogen activator inhibitor type 1 levels (PAI-1) |
| BLCA | cis | rs4343996 | 1 | rs6980323 | chr7:3356207 | SDK1 | chr7:3341080-4308629:+ | 0.24 | 3.88 | 0.000124 | Motion sickness |
| BLCA | cis | rs6989010 | 1 | rs6989010 | chr8:12772755 | FAM86B1 | chr8:12039614-12051624:- | -0.56 | -4.09 | 5.2E-5 | Colorectal cancer (diet interaction) |
| BLCA | cis | rs7017914 | 1 | rs7007450 | chr8:71640269 | XKR9 | chr8:71581600-71648176:+ | 0.82 | 17.69 | 1.34E-51 | Bone mineral density |
| BLCA | cis | rs7017914 | 1 | rs7017914 | chr8:71591203 | XKR9 | chr8:71581600-71648176:+ | 0.82 | 18.12 | 1.88E-53 | Bone mineral density |
| BLCA | cis | rs7029536 | 1 | rs7029536 | chr9:130110411 | SLC2A8 | chr9:130159465-130170161:+ | -0.29 | -5.42 | 1.04E-7 | Metabolite levels (HVA) |